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KMID : 0378119840110020259
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Chungnam Medical Journal
1984 Volume.11 No. 2 p.259 ~ p.264
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A Comparison of Atropine and Glycopyrrolate in Anesthetic Field
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Abstract
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When antagonism of nondepolarzing neuromuscular Mock is required, atrpine has been used as an anticholinergic drug to counteract the muscarinic actions of neostigmine.
Glycopyrrolate is a potent, long-acting anticholinergic agent and recently it has been recommended as a suitable alternative to atropine.
This study was undertaken to determine whether glycopyrrolate does offer any difference from atropine in heart rate, arrhythmia, blood pressure, and oropharyngeal secretion.
On 40 patients anesthetized with balanced techniques, the neuromuscular block produced by pancuronium was reversed with (Group I ) atropine-neostigmine (1. Omg : 2.5mg) or (GroupⅡ) glycopyrrolate-neostigmine (0.4 mg : 2.5mg) mixture.
The results are as follows :
1. The safely and effectivenss of both groups in antagonizing the muscarinc actiosn of neostigmine were demonstrated.
2. Glycopyrrolate group was superior to atropine group in producing less increased heart rate.
3. Glycoprrrolate group was superior to atropine group in protuctinT lower incidence of bradycardia.
4. Glycopyrrolate was superior to atropine in the antisalirary action.
5. There were no significant differences on the incidence of arrhythmias in both groups.
It is concluded that glycopyrrolate is an effective antimuscarinic agent and could be safely used as an alternative to atropine.
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